Night Time Weight Loss Drops: Discover the Powerful Ingredients, Real Effectiveness & Safety Tips!

The pursuit of effective weight loss solutions has led to the development of various dietary supplements, including night time weight loss drops. These products often contain a blend of ingredients purported to boost metabolism, reduce fat absorption, or promote fat burning during sleep. While the idea of losing weight while you sleep is appealing, it's crucial to examine the ingredients, effectiveness, and safety of these supplements.

The Allure of Fat Burners

Fat burners are dietary supplements marketed to increase metabolism, reduce fat absorption, or help the body burn more fat. Manufacturers frequently promote them as miracle solutions for weight loss. However, it's important to approach these claims with skepticism.

Questionable Effectiveness and Potential Harm

According to a 2011 study, fat burners are often ineffective and may even be harmful. There is no miracle pill for weight loss, and even “natural supplements” cannot guarantee fat loss. Everyone’s metabolism is different. The most effective way to lose weight is through consistent habits: regular sleep, decreased stress, regular exercise, and eating a nutrient-rich, healthy diet.

Natural Supplements with Potential Benefits

That said, several natural supplements have been proven to help you burn more fat. These natural solutions include caffeine, green tea extract, protein supplements, soluble fiber supplements, and yohimbine. Caffeine, green tea extract, and protein supplements are likely to be the most effective at helping you burn fat.

Caffeine

Caffeine is a substance commonly found in coffee, green tea, and cocoa beans. It’s also a popular ingredient in commercial fat-burning supplements - and for good reason. A 2021 review of studies suggests that the caffeine in coffee can prevent and reduce fat stores in the body. It can also boost your metabolism and help your body burn additional fat. A 2024 study found that caffeine can boost basal metabolic rates by increasing systemic catecholamine levels. Catecholamines are molecules that act as neurotransmitters and hormones; they include dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline). To reap the benefits of caffeine, you don’t need to take a dietary supplement. You can try drinking strong coffee, which is an excellent source of caffeine with many health benefits. That said, these health benefits are only temporary. Plus, it’s important to note that caffeine can interfere with quality sleep, which has negative effects on weight management.

Green Tea Extract

Green tea extract is simply a concentrated form of green tea. It provides all the benefits of green tea in a convenient powder or capsule form. In addition, these two compounds complement each other and can help you burn fat through a process called thermogenesis. In simple terms, thermogenesis is a process in which your body burns calories to produce heat. For instance, an analysis of six studies found that taking a combination of green tea extract and caffeine helped people burn 16% more fat than a placebo. In an earlier study, scientists compared the effects of a placebo, caffeine, and a combination of green tea extract and caffeine on burning fat. They discovered that the combination of green tea and caffeine burned roughly 65 more calories per day than caffeine alone and 80 more calories than the placebo. Keep in mind that participants in these studies took green tea extract in combination with additional caffeine. Therefore, this does not definitively show that green tea extract alone has these same effects. Studies have shown that while no detrimental effects have been reported from green tea itself, excess consumption may prove to be harmful to the liver, particularly if taken on an empty stomach. Do not exceed the recommended dosage.

Protein Supplements

Protein is incredibly important for burning fat. A high protein intake can help you burn fat by boosting your metabolism and curbing your appetite. It also helps your body preserve muscle mass. Research has also shown that protein-enriched diets can lead to greater weight loss and improvements in metabolic biomarkers. Protein can also curb your appetite by increasing the levels of fullness hormones like GLP-1, CCK, and PYY while reducing levels of the hunger hormone ghrelin. While you can get all the protein you need from protein-rich foods, many people still find it challenging to eat enough protein daily. Protein powder supplements are a convenient way to increase your protein intake. Options include whey, casein, soy, egg, and hemp protein powders. However, it’s important to choose a protein supplement that’s low in sugar and additives, especially if you’re trying to lose weight. Keep in mind that calories are still important. Protein supplements should replace snacks or be part of a meal rather than an extra addition to your diet. This is especially true if you’re trying to lose weight by maintaining a calorie deficit. If you’re finding it difficult to eat enough protein, try taking 1 to 2 scoops (25 to 50 grams) of protein powder per day. The recommended daily intake of protein will vary based on your activity levels, age, sex, weight, height, etc. That said, the Recommended Dietary Allowance (RDA) for protein is 0.8 grams of protein per kilogram of body weight.

Soluble Fiber Supplements

There are two different types of fiber: soluble and insoluble. Interestingly, studies have shown that soluble fiber can help you burn fat by curbing your appetite. In addition, soluble fiber helps slow down the delivery of nutrients to the gut. When this happens, your body takes more time to digest and absorb nutrients, which can leave you feeling full for longer. What’s more, soluble fiber may also help you burn fat by reducing how many calories you absorb from food. While you can get all the soluble fiber you need from food, many people find this challenging. If that’s the case for you, try taking a soluble fiber supplement such as glucomannan or psyllium husk.

Yohimbine

Yohimbine is a substance found in the bark of Pausinystalia yohimbe, a tree found in Central and Western Africa. It’s commonly used as an aphrodisiac, but it also has properties that may help you burn fat. Yohimbine works by blocking receptors called alpha-2 adrenergic receptors. These receptors normally bind adrenaline to suppress its effects, one of which is encouraging the body to burn fat for fuel. Since yohimbine blocks these receptors, it can prolong adrenaline’s effects and promote the breakdown of fat for fuel. A 2006 study involving 20 elite soccer players found that taking 10 mg of yohimbine twice daily helped them shed 2.2% of their body fat, on average, in only 3 weeks. Keep in mind that these athletes were already quite lean, so a 2.2% reduction in body fat is significant. A more recent 2024 study also found therapeutic potential in yohimbe for weight loss. However, researchers expressed concern about potential toxic effects, particularly at higher doses. Because yohimbine keeps your adrenaline levels elevated, it may cause side effects like: nausea, anxiety, panic attacks, and high blood pressure. Yohimbe can also interact with common medications for blood pressure and depression. If you take medications for these conditions or have anxiety, you might want to avoid yohimbine. More clinical research is needed on yohimbine before it can be recommended as a go-to fat-burning supplement.

The Danger of Hidden Ingredients

Commercial fat-burning supplements are widely available and very easy to access. However, they often do not live up to their hefty claims and may even harm your health. That’s because fat-burning supplements do not need to be approved by the Food and Drug Administration before they can be sold on the market. Instead, it’s the manufacturer’s responsibility to ensure that their supplements are tested for safety and effectiveness. And many fat-burning supplements have been pulled off the market because they were tainted with harmful ingredients. There have even been cases in which contaminated supplements caused dangerous side effects like high blood pressure, strokes, seizures, and even death. Remember that a supplement cannot replace health-promoting activities like exercising and eating a balanced, nutrient-rich diet. Talk with a doctor if you’re interested in developing a healthy program that can help you manage your weight.

Read also: The Power of Oranges

Examples of Recalled Products

The FDA has issued numerous public notifications regarding weight loss products found to contain hidden and potentially dangerous ingredients. Here are some examples:

FATZorb (07/22/2025)
Toki Slimming Candy (06/24/2025)
LipoFit Turbo (11/27/2024)
THERMO SHOCK (11/22/2024)
ITCHA XS (10/30/2024)
Body Shape Weight Loss System (10/02/2024)
Govvi WOW! (12/21/2023)
Phentamene XT (5/05/2023)
NORF 20 (5/01/2023)
Alfia Weight Loss Capsules (2/08/2023)
Lipopastilla + Gold Max (7/22/2022)
Dr. Reade Slim Sense (7/15/2022)
Hydro Pinapple [sic] Burn (7/26/2021)
Cholestene (7/09/2021)
Genesis Ultra Slim Gold (7/01/2021)
365 SKINNY High Intensity (6/30/2021)
Miss Slim (6/04/2021)
Tummy Tuck Max (4/29/2021)
Vy & Tea (2/26/2021)
Super Slim (12/17/2020)
Lishou Slimming Coffee (12/17/2020)
Li Da Daidaihua Plus (12/17/2020)
Imperla Elita Vitaccino (12/17/2020)
Fruta Planta (12/17/2020)
Fruta Bio (12/17/2020)
Burn 7 (12/17/2020)
Livtone (11/18/2020)
Detox Plus (12/04/2019)
CholesLo (10/24/2019)
Skinny Pill (10/17/2019)
Lanugar (9/06/2019)
JaDera PLUS (9/06/2019)
Sheaya Lender (9/06/2019)
Love in S (9/06/2019)
Reduktis Max (7/16/2019)
Lipro Dietary Capsule (7/01/2019)
Adelgasin Plus (6/26/2019)
Super Slimming Herb (6/26/2019)
Lishou Fuling Jiaonang (6/26/2019)
Detoxi Slim (6/26/2019)
Absolute Nine Slim (6/26/2019)
GoLean Detox (1/28/2019)
Ultra Fit (1/28/2019)
Slimmer Extreme Thermogenic Formula (1/28/2019)
Slim Bio Capsules (1/28/2019)
Slimina (1/28/2019)
Pink Granada (11/21/2018)
Green Lean Body Capsule (10/01/2018)
Shengan Natural Model (10/01/2018)
Like Slim Coffee (10/01/2018)
In Shape (10/01/2018)
Baschi Quick Slimming Capsule (10/01/2018)
BodySlim Herbal (8/31/2018)
Easy 2 Slim (8/31/2018)
Slimming Capsule (8/31/2018)
Nuvitra (8/10/2018)
Asunsa (7/09/2018)
Lyn DTOX FS3 (7/09/2018)
Adipotrim XT (7/03/2018)
Body Shape Weight Loss System (7/03/2018)
Row of Antibody Pil (7/03/2018)
Adriana Balance S (6/20/2018)
AB Slim (6/20/2018)
PAYA Dietary Supplement Product (6/07/2018)
Asia Slim Capsules (11/22/2017)
Adipessum Miracle Slimming Capsules (11/20/2017)
Fruta Planta Life (Garcinia Cambogia Premium) (11/20/2017)
A1 Slim (10/03/2017)
Physic Candy - Define (8/31/2017)
Physic Candy - Curve (8/31/2017)
Slimming Plus Advanced (2/03/2017)
Platinum Weight Loss Solution - Fat Loss Metabolizer (2/03/2017)
Platinum Max Strength Blue Pill Version (2/03/2017)
Lean Extreme Max (2/02/2017)
X-treme Beauty Slim (2/02/2017)
Queen Slimming Soft Gel (12/22/2016)
ABX Weight Loss (11/16/2016)
Supreme Slim 5.7 (11/09/2016)
Ultimate Body Tox (11/07/2016)
Zi Su Body Fat Health II (10/25/2016)
Skinny Bee Diet (10/19/2016)
Results (10/19/2016)
Accelerator Boost (10/19/2016)
Natural Eruption (8/16/2016)
Citrus' Fit (8/09/2016)
Adelganzantes R-II (8/09/2016)
Zi Xiu Tang Beauty Face and Figure Capsule (7/28/2016)
Ultimate Lean (7/28/2016)
Slim Fit X (7/27/2016)
Maxx Easy (7/27/2016)
Mang Luk Power Slim (7/27/2016)
Mang Luk Power Slim Detox (7/27/2016)
Xcelerated Weight Loss Ultra Max (7/22/2016)
Xcelerated Weight Loss Turbo Charge (7/22/2016)
Xcelerated Weight Loss Charged Up (7/22/2016)
Dream Body Advanced Acai Weight Loss (7/11/2016)
Dream Body Extreme Gold (7/11/2016)
Dream Body Original Formula (7/11/2016)
Extra Slim Plus Acai Berry Weight Loss Formula (7/11/2016)
Exhilarate (7/11/2016)
Step 2 (6/06/2016)
Black Label X (5/06/2016)
Black Gold X Advanced (4/26/2016)
3rd Degree (4/26/2016)
Propell Platinum (3/28/2016)
ENVY BP (3/29/2016)
ZlimXter Capsules (3/17/2016)
Xerophagy Capsules (3/17/2016)
Eradicate Capsules (3/17/2016)
Dynamizm Capsules (3/17/2016)
La'Trim Plus (12/21/2015)
Evolve Bee Pollen (12/18/2015)
Jenesis (12/18/2015)
Oasis Bee Pollen (12/18/2015)
Prime Bee Pollen (12/18/2015)
Thirty Plus (12/17/2015)
Lipo Escultura (12/02/2015)
Zero Fat (11/19/2015)
SPCARET Princess Diet (11/19/2015)
Slyn Both (11/19/2015)
Perfect Slim Fast Track Slim (11/19/2015)
Super Herbs (11/19/2015)
Xtreme Fat Burner Capsules (10/23/2015)
Tip-Top Shape (10/23/2015)
Lishou Slimming Coffee (10/23/2015)
Basha Nut 100% Fruit Soft Gel Capsules (10/23/2015)
Ultimate Herbal Slimcap (10/01/2015)
NATUREAL (10/01/2015)
Meizi Super Power Fruits Herbal Slimming Formula (9/03/2015)
Achieving Zero (8/06/2015)
Zero Xtreme Capsules (7/02/2015)
Akttive Capsules (7/02/2015)
Slim Forte Slimming Capsule (4/30/2015)
Li Da Dai Dai Hua Slimming Capsule (4/30/2015)
Fatloss Slimming Beauty (4/29/2015)
Superior (4/29/2015)
Green Algae Combination by Crane Beauty (3/26/2015)
Xcel Advanced (3/18/2015)
Xcel (3/18/2015)
Ultimate Boost (3/18/2015)
L-Carnitine Sob Strengthening Version Slimming Miracle Capsule (3/05/2015)
Black Mamba Hyperrush (3/05/2015)
Natural Max Slimming (3/03/2015)
Diablos Eca Fire Caps (3/03/2015)
Eliminating Weight (3/02/2015)
Oxy ELITE Pro Super Thermogenic (2/28/2015)
Nine Slim (2/28/2015)
Seven Slim (2/28/2015)
Botanical Slimming (Red) (7/27/2015)
Lean Body Extreme (2/25/2015)
Yanhee Slim (2/03/2015)
Slim-K (12/23/2014)
Slim-Vie (11/25/2014)
Super Extreme Accelerator (11/24/2014)
Japan Hokkaido Slimming Weight Loss Pills (9/12/2014)
Mix Fruit Slimming (7/08/2014)
Lingzhi Cleansed Slim Tea (7/08/2014)
24 Ince (7/08/2014)
Lipo 8 Burn Slim Capsules (7/08/2014)
Sliming (sic) Diet By Pretty White (7/08/2014)
Trim-Fast Slimming Softgel (7/08/2014)
Sport Burner (6/17/2014)
Toxin Discharged Tea (6/17/2014)
Sliming Diet (6/17/2014)
La Jiao Shou Shen (06/10/2014)
B-Perfect (6/05/2014)
Asset Bold (5/16/2014)
Asset Bee Pollen (5/12/2014)
Natural Body Solution (5/05/2014)
Slim Trim U (5/05/2014)
Lite Fit USA (4/10/2014)
Infinity (4/10/2014)
New You (4/02/2014)
Vitaccino Coffee (3/19/2014)
Citrus Fit Gold (1/28/2014)
Tonic Life BP (1/28/2014)
Thinogenics (1/28/2014)
Dream Body Slimming Capsule (1/21/2014)
Meizitang Citrus (12/19/2013)
Asset Extreme Plus (12/19/2013)
7 Days Herbal Slim (12/19/2013)
Dr. Ming's Chinese Capsule (12/19/2013)
SlimEasy Herbs Capsule (12/19/2013)
Sliming (sic) Diet Berry Plus (12/19/2013)
Asset Extreme (12/19/2013)
"SlimExtra Herbal Capsules" (12/19/2013)

This list is not exhaustive, but it illustrates the prevalence of adulterated weight loss supplements on the market.

A Cautionary Tale: Herbal Remedies and Liver Toxicity

Globally, people are struggling with obesity. Many effective, non-conventional methods of weight reduction, such as herbal and natural dietary supplements, are increasingly being sought. Despite patient perceptions that herbal remedies are free of adverse effects, some supplements are associated with severe hepatotoxicity. The present report describes a young healthy woman who presented with fulminant hepatic failure requiring emergent liver transplantation caused by a dietary supplement and fat burner containing usnic acid, green tea and guggul tree extracts. Thorough investigation, including histopathological examination, revealed no other cause of hepatotoxicity. The present case adds to the increasing number of reports of hepatotoxicity associated with dietary supplements containing usnic acid, and highlights that herbal extracts from green tea or guggul tree may not be free of adverse effects.

In recent years, there has been an alarming increase in obesity worldwide. Growing numbers of obese individuals are struggling to find the best way to lose weight. This has created an enormous industry for weight loss and related health products. Because they are not subject to regulatory testing by the United States Food and Drug Administration (FDA), herbal remedies continue to be a popular choice due to their perceived safety and easy availability. Among the more popular remedies are the ‘fat burners’. These supplements are advertised to work by increasing thermogenesis and the basal metabolic rate, thus, mimicking exercise. Several slimming aids and herbal medications associated with severe hepatotoxicity have been reported in the literature.

Case Study: A Bodybuilder's Experience

A previously healthy 28-year-old female bodybuilder with no risk factors for liver disease presented to her local emergency centre with fatigue, malaise, inability to exercise and new-onset jaundice. Her symptoms worsened over a span of one week before hospitalization. The patient was a professional bodybuilder taking a multi-ingredient, nonstimulant health supplement and fat burner (Somalyz and Lipolyz, Species Nutrition, USA).

Read also: Nutritional Value of Muskmelon

Somalyz contains usnic acid (4 mg), propionyl-L-carnitine (167 mg), phosphatidylcholine/phosphatidylethanolamine (50 mg), gamma-aminobutyric acid (667 mg) and vitamin E (27 IU) per capsule. Lipolyz contains usnic acid (12 mg), propionyl-L-carnitine (500 mg), green tea extract (300 mg), guggulsterone Z and guggulster-one E (10 mg), cyclic adenosine monophosphate (2 mg) and vitamin E (20 IU) per capsule. She was taking one to two capsules of Somalyz at bedtime and one capsule of Lipolyz with meals three times a day as recommended for one month before illness.

On evaluation at The Mount Sinai Medical Center, there were no stigmata of chronic liver disease. Blood work revealed a total serum bilirubin level of 82.08 mmol/L (normal range 1.71 mmol/L to 20.5 mmol/L), a direct bilirubin level of 47.88 mmol/L (1.71 mmol/L to 13.6 mmol/L), a serum alanine aminotransferase level of 1220 U/L (1 U/L to 53 U/L), a serum aspartate aminotransferase level of 577 U/L (1 U/L to 50 U/L), an alkaline phosphatase level of 111U/L (30 U/L to 110 U/L), a gamma-glutamyl transferase level of 125 U/L (8 U/L to 35 U/L), an international normalized ratio of 2.6 and a serum creatinine level of 53.04 μmol/L (44.2 μmol/L to 106.2 μmol/L). Etiological workup included the following: negative viral serology (hepatitis A virus immunoglobulin M, hepatitis B virus surface antigen and core antibody, hepatitis C virus antibody [polymerase chain reaction assay], cytomegalovirus DNA and Epstein-Barr virus immunoglobulin M); negative syphilis rapid plasma regain; negative autoimmune markers (antinuclear antibody, antiliver kidney muscle antibody, antimitochondrial antibody and antismooth muscle antibody); and normal serum gamma globulins. Extensive toxicology screening was negative, with no features of acetaminophen toxicity (acidosis, high lactate or renal failure). She had normal levels of ferritin, ceruloplasmin and alpha-1 antitrypsin. A pregnancy test was negative. A computed tomography scan of her abdomen revealed a normal size liver with a patent portal vein, hepatic artery, hepatic vein and normal biliary anatomy. The patient’s encephalopathy worsened and she remained unresponsive. A computed tomography scan of her head was normal. An intracranial pressure monitor was placed, which measured an intracranial pressure of 19 mmHg and a cerebral perfusion pressure of 77 mmHg to 82 mmHg. She underwent successful cadaveric orthotopic liver transplantation on hospital day 2. By postoperative day 4, she was awake and alert.

Histology of the native explanted liver showed confluent necrosis resulting in parenchymal collapse. Reticulin stain confirmed the extensive parenchymal collapse. High-power magnification showed the formation of ductular hepatocytes in periportal areas.

The Role of Usnic Acid and Other Ingredients

Usnic acid is a component of nutritional supplements that are promoted for weight loss and have been associated with liver-related adverse events including mild hepatic toxicity, chemical hepatitis and liver failure requiring liver transplantation. Usnic acid is derived from a lichen species of the genus Usnea. It has been investigated for diverse uses as an antimicrobial, an anti-inflammatory, an antioxidant, an analgesic/antipyretic, an antiproliferative and as a natural supplement for weight loss. Several previous reports described liver failure associated with the use of LipoKinetix, a multi-ingredient preparation containing usnic acid. In 2002, Favreau et al reported on seven patients who developed acute hepatitis after using LipoKinetix. This dietary supplement contains sodium usniate, norephedrine, yohimbine, 3-5-diiodothyronine and caffeine; both usnic acid and ephedra alkaloids have been associated with severe hepatotoxicity. Sanchez et al reported severe hepatotoxicity in a husband and wife (both 38 years of age) who were bodybuilders taking the multi-ingredient health supplement UCP-1 (BDC Nutrition, USA) for three months. UCP-1 contains usnic acid (150 mg), L-carnitine (525 mg) and calcium pyruvate (1050 mg) per capsule. The wife developed fulminant hepatic failure requiring liver transplantation. The husband experienced submassive necrosis but did not require liver transplantation. Another herbal remedy containing usnic acid - well known to be hepatotoxic - is kombucha tea.

Usnic acid has been shown to uncouple oxidative phosphorylation in a murine model, with resultant loss of mitochondrial respiratory control and inhibition of ATP synthesis. A direct hepatotoxic effect analogous to carbon tetrachloride-induced liver toxicity has also been described. Usnic acid is a weak inhibitor of cytochrome CYP2D6 and a potent inhibitor of cytochrome CYP2C19. Based on potent inhibition of CYP2C enzymes, usnic acid has significant potential to interact with other medications.

Chinese green tea extracts are derivatives of the leaves of Camellia sinensis, which belongs to the aceae family. Green tea extracts have been marketed as effective weight-loss supplements, and for the prevention and cure of solid tumours. Although there is little scientific evidence supporting the effectiveness of green tea extracts, serious side effects, including acute liver failure, are increasingly being reported. Similar cases have been reported from France and Spain resulting in the removal of the green tea extract ‘Exolise’ from the market. Two cases of fulminant hepatic failure associated with green tea extracts have been reported. Mitochondrial toxicity and the formation of reactive oxygen species have been demonstrated with epigallocatechin-3-gallate, a key constituent of green tea extracts.

Gum guggul and its constituents are increasingly being used as dietary supplements. Gum guggul is the oleoresin of Commiphora mukul, a plant native to India. Its extracts include compounds known for their hypolipidemic properties - the Z and E isomers of guggulsterone and its regulated guggulsterols. Human exposure to gum guggul most often occurs from ingesting herbal remedies or pharmaceuticals, and from the use of cosmetics. Side effects include skin rashes, irregular menstruation, diarrhea, headache, mild nausea and, with very high doses, liver toxicity.

Regulatory Loopholes and the Need for Caution

Based on the temporal relationship between the use of the dietary supplements and onset of liver failure, literature supporting reports of hepatotoxicity associated with dietary supplements and exclusion of other causes, it is fair to assume that the patient developed fulminant hepatic failure due to dietary supplements. In view of the bulk of the literature, of all the ingredients, usnic acid may have been predominantly responsible for the hepatoxicity.

According to the Dietary Supplement Health and Education Act of 1994, dietary supplements are regulated as foods and are not subject to regulation as drugs by the FDA; manufacturers are not compelled to provide safety data to the FDA. However, increasing reports of liver failure due to usnic acid have triggered a regulatory warning and one voluntary product withdrawal (LipoKinetix). Usnic acid is still available and advertised on the Internet as an ingredient in various other dietary supplements and fat burners.

Night Time Metabolic Support: A Closer Look

Some night time weight loss drops focus on supporting metabolic health, managing stress, and curbing sugar cravings. One such product contains ingredients like:

Ashwagandha Root: Supports the body's stress response.
Gymnema Leaf: Helps curb sugar cravings.
Maca Root: Helps increase energy levels.
Blue Spirulina: Promotes healthy metabolism.
Oregon Grape Root: Supports blood sugar levels and immunity.
Cinnamon & Ginger: Supports circulation and digestion.

While these ingredients may offer some benefits, it's crucial to remember that the FDA has not evaluated these statements. This product is not intended to diagnose, treat, cure, or prevent any disease. If you are pregnant, nursing, have a medical condition, or take medications, consult your physician before use. Do not use if seal is broken or damaged. Store out of light and heat. Keep out of reach of children.

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