Fad diets often promise quick fixes, but sustainable weight loss requires a comprehensive approach. The allure of a pill that curbs hunger, burns fat, and heals metabolism is strong, but it's crucial to distinguish between science-based solutions and marketing hype. While the GOLO diet, with its Release supplement, has gained popularity by framing its approach around insulin resistance, a closer look reveals a complex picture. This article will delve into the potential benefits of gold, specifically gold nanoparticles (AuNPs), in weight loss, while also examining the GOLO diet and other weight loss strategies.
The GOLO Diet: A Closer Look
The GOLO diet is a weight loss plan centered on the idea that insulin resistance causes hunger, cravings, overeating, and ultimately, weight gain. By combining the GOLO Release supplement with the GOLO for Life Food Plan, the company claims to restore metabolic efficiency and maintain an optimal weight.
How the GOLO Diet Works
The core concept behind the GOLO diet is that insulin resistance is at the root of weight problems. Insulin resistance occurs when cells become less responsive to insulin over time, hindering their ability to take up glucose (or sugar) from the blood efficiently. The body then produces more insulin to clear the glucose, potentially leading to increased appetite and weight gain.
The GOLO Diet claims that its proprietary supplement, Release, can help control insulin and promote weight loss without dieting, when paired with the GOLO For Life Food Plan. The GOLO Food for Life Plan supplies between 1,300 and 1,800 calories per day through mostly unprocessed foods, potentially creating a calorie deficit.
GOLO Diet Foods: What You’ll Eat on the Plan
The GOLO diet emphasizes whole foods over heavily processed ones. It recommends eating foods in the correct balance, which entails eating mostly protein, then non-starchy veggies, a small amount of starchy carbs (such as fruit, starchy veggies, or whole grains, and a small amount of fat. Unprocessed, protein-heavy snacks are allowed, but most sweets and processed foods are limited.
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Here are some of the foods you’ll eat on the GOLO Diet:
- Vegetables: salad greens, asparagus, broccoli, carrots, and zucchini
- Fruit: strawberries, grapefruit, bananas
- Carbohydrates: whole-wheat bread, whole-wheat pasta, steel-cut oats, brown rice
- Dairy: whole milk, cottage cheese, Greek yogurt
- Protein: eggs, lean meat, fish, tofu
- Fats: nuts, seeds, avocado, olive oil
Concerns and Considerations Regarding the GOLO Diet
While the GOLO diet emphasizes whole foods, which is a good strategy for managing weight, the evidence behind the plan is weak. The research quality is low, all of it is sponsored by the company, involves very small populations for a short period of time and most isn’t published in peer-reviewed journals.
The GOLO diet and pill isn't a fit for everyone. Those who are pregnant or nursing, have a medical condition, including insulin resistance, prediabetes or Type 2 diabetes, or are a chronic dieter or have any disordered eating habits should think twice about the GOLO diet.
It’s important to consult your physician first, as they may recommend an alternative, including perhaps a prescription medication, that would be better suited for you.
Sample Day on the GOLO Diet
Here’s a sample plan that reflects the GOLO diet method of prioritizing protein, filling up on non-starchy veggies, including a controlled portion of starchy carbs and a small amount of fat.
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- Breakfast: Scrambled eggs with spinach, mushrooms, and onions. Half a grapefruit and a few slices of avocado
- Lunch: Grilled chicken breast, a large salad with mixed greens, cherry tomatoes, cucumbers, and shredded carrots with a drizzle of olive oil and vinegar dressing. Small serving of quinoa or brown rice
- Snack (optional): Plain Greek yogurt with a few berries and a sprinkle of flax seeds
- Dinner: Baked salmon, steamed broccoli and roasted zucchini tossed with some chopped walnuts and a small portion of roasted sweet potato wedges
The Potential of Gold Nanoparticles (AuNPs) in Weight Loss
Recent research has explored the potential of gold nanoparticles (AuNPs) in addressing obesity and related metabolic disorders. One study investigated whether AuNPs could benefit mice with pre-existing obesity.
Study Design and Results
Male C57BL/6 mice were fed a high-fat diet (HFD) for 15 weeks. AuNPs were administered to subgroups of HFD-fed mice over the last 5 weeks. The study found that only the OB-LAu group (receiving a specific dose of AuNPs) demonstrated significant weight loss (12%), while all AuNP treated groups showed improved glycaemic control and reduced blood lipid levels.
In the fat tissue, mRNA expression of pro-inflammatory markers were unchanged following AuNP treatment, while glucose and lipid metabolic markers were improved in OB-LAu and OB-HAu mice.
Implications of the Findings
The study suggests that AuNP treatment can improve glucose and fat metabolism in mice with long-term obesity. However, weight loss was only observed in a single specific dose regime, highlighting the importance of dosage in achieving desired outcomes.
Mechanisms of Action
The study also explored the potential mechanisms by which AuNPs exert their effects. It was found that alterations resulting from the AuNP treatment in macrophage inflammatory responses in the liver and changes to metabolic regulators in both fat and liver tissue, are the likely underlying mechanisms.
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Long term consumption of a HFD in mice induced hyperphagia, dietary obesity and dyslipidaemia, along with subsequently developed metabolic disorders including glucose intolerance, excessive weight gain and increased fat mass, which are consistent with our previous observations. Only the low dose AuNP treatment regime led to clinically significant total weight loss (12% reduction) along with fat loss effects within 5 weeks.
Comparison to Existing Weight Loss Treatments
The study mentions that weight loss greater than 5% is sufficient to improve glycaemic control and life quality in obese individuals who also have a high risk of diabetes and cardiovascular diseases. The AuNP treatment used in this study, induced significant levels of weight loss without changes to dietary intake. In addition, glycaemic control in the same OB-LAu treated group was nearly normalized compared to the vehicle treated obese mice.
Safety Considerations
The AuNP-treated mice demonstrated above baseline levels of gold in their abdominal fat, liver, spleen, kidney, heart and brain, in decreasing order. The increased levels of gold found in the abdominal fat, liver, spleen and heart reflected a dose-dependent pattern, however, significance was only observed in the high dose group compared to the other two treatment groups.
Turmeric and Weight Loss: Exploring the Golden Spice
Turmeric, also known as the golden spice, is popular in Asian cuisine and has been a part of traditional Indian medicine - or Ayurveda - for thousands of years. Most of turmeric’s health properties can be attributed to curcumin, a compound that has strong antioxidant and anti-inflammatory properties.
The Role of Curcumin
Recent research has examined turmeric’s role in weight loss. In fact, a 2023 review suggests that curcumin may suppress particular inflammatory markers that play a role in obesity. These markers are typically elevated in people with excess weight or obesity. A 2022 review noted that curcumin is a promising natural compound that may help with weight loss; however, more studies are needed before turmeric can be recommended as a weight management or preventive measure.
Safety and Dosage
In general, turmeric and curcumin are considered safe. The World Health Organization (WHO) suggests a range of 0-3 mg per kilogram of body weight as a safe daily intake. Nonetheless, some people who take large doses of this compound may experience adverse effects, such as allergic reactions, nausea, vomiting, stomach pain, constipation, skin rash, and diarrhea.
Also, those with bleeding disorders, iron deficiency, or kidney stones should avoid turmeric supplements. Note that there’s insufficient evidence regarding the safety of these supplements among pregnant or breastfeeding people.
Forms of Turmeric
Turmeric comes in several forms, though the easiest way to use it is as a cooking spice. It’s also enjoyed in beverages like turmeric ginger tea and golden milk, which is made by heating milk, turmeric, ginger, black pepper, and cinnamon powder.
Bravenly Gold: A Turmeric-Based Supplement
Bravenly GOLD was formulated to support gut health, a strong immune system, and radiant skin. It combines turmeric, freshly ground black pepper, and cinnamon for maximum benefits and a smooth, balanced flavor. Black pepper supports the absorption of turmeric’s active compound, curcumin, while cinnamon adds a naturally sweet finish to complement turmeric’s earthy notes.
The Bravenly Proprietary Blend includes:
- Turmeric (Powder)
- Coconut (Powder)
- Garcinia Cambogia (Powder)
- Apple Cider Vinegar (Powder)
- Maitake Mushrooms (Extract)
- Black Pepper (Extract)
- Cinnamon (Powder)
- Turmeric (Extract)
Potential Benefits of Golden Milk
Golden milk contains antioxidant and anti-inflammatory compounds, which may offer health benefits, including protection against certain diseases. The ingredients in golden milk have powerful anti-inflammatory properties and may reduce joint pain from osteoarthritis and rheumatoid arthritis.
Studies show that curcumin may increase levels of brain-derived neurotrophic factor (BDNF). BDNF is a compound that helps your brain form new connections and promotes the growth of brain cells. Curcumin may boost mood and reduce symptoms of depression. Cinnamon, ginger, and turmeric - the key ingredients in golden milk - have all been linked to a lower risk of heart disease. The ingredients in golden milk, particularly ginger and cinnamon, may help lower blood sugar levels. Some research suggests that the spices used in golden milk may offer some benefits in regard to cancer. The ingredients in golden milk also have potent antioxidant and anti-inflammatory properties, which may strengthen your immune system. Ginger, one of the ingredients in golden milk, may help relieve chronic indigestion by speeding up stomach emptying in people with dyspepsia. Turmeric may also improve fat digestion by increasing bile production. Golden milk may contribute to a strong skeleton, as both cow’s and enriched plant milks are generally rich in calcium and vitamin D - two nutrients essential for building and maintaining strong bones.
Metabolic Gold: Supporting Metabolic Health
Metabolic Gold features a unique blend of high-strength bergamot polyphenols, artichoke, and baobab to support a healthy metabolism, balancing cholesterol and sugar levels. It contains high-strength bergamot, with 40% polyphenols, to support liver function and healthy cholesterol levels. With artichoke, this unique formula optimises fat and sugar balance, reduces sugar cravings for healthy weight management.
The benefits of Bergamot are supported by over 20 human clinical trials. The studies found that Bergamot supports sugar control, cholesterol balance, and liver health. The benefits of Artichoke are supported by over 14 human clinical trials. Metabolic Gold can support weight management by improving sugar control and improved metabolism.
Alternative Weight Loss Strategies
The Role of GLP-1 Medications
GLP-1 drugs (Ozempic, Mounjaro, Wegovy, etc.) may be costly and do not address the underlying causes of weight gain or teach you how to keep the weight off long-term. They rely on turning off your body’s natural hunger signal, interrupting the gut-brain connection. Because these drugs suppress your appetite, they may prevent you from getting the essential nutrients your body needs and put you at risk for potential side effects. Worse, once the medication is stopped, many people regain the weight - creating long-term dependency, which benefits the pharmaceutical industry.
Sustainable Lifestyle Changes
An unbalanced diet affects insulin effectiveness. It increases glucose levels and spikes insulin levels, causing excess glucose to be stored as fat. Starving the body for weight loss leads to muscle loss and a slower metabolism. With GOLO, you can safely and effectively control sugar cravings and hunger and minimize muscle loss as you lose weight. With GOLO, slow and steady truly wins the race.
The Importance of Individualized Approaches
One thing we know by now is losing weight can be challenging. Also, keep in mind that we’re all individuals and just because a program works for one person, it doesn’t mean it will work for you. Likewise, bodies are unique and diverse, and it’s not necessary to achieve the version of thin you see on TV (and elsewhere) to be healthy.