Obesity, a global health crisis, is associated with increased adverse health outcomes such as mortality, cancer, cardiovascular diseases, dementia, and other chronic diseases. With its fast-rising prevalence, obesity brings a heavy burden on the healthcare system. Vitamin B may play an important role in the development of obesity and other metabolic diseases by affecting energy metabolism, oxidative stress, inflammatory response, and lipid metabolism.
The B vitamins are a group of eight essential nutrients that play vital roles in various bodily functions. They are thiamine (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5), pyridoxine (B6), biotin (B7), folate (B9), and cobalamin (B12). These vitamins are crucial for maintaining overall health and well-being. They are essential for normal physiological function but cannot be made or stored in the body itself, so they must be obtained from the diet or from supplements.
Understanding the B Vitamins
Most of the B vitamins are found in a wide range of foods because they are so important to cellular function. Some, like vitamin B12, are found mostly in meat and other animal food sources. You might need a B complex supplement if you can't get the recommended daily amount of B vitamins from your diet.
The B vitamins have many roles. Thiamine, riboflavin, niacin, pantothenic acid, and biotin help convert food to energy, and help your cells grow, develop, and function. They also have their own unique roles:
- Thiamine (B1): Helps keep your nervous system healthy. Thiamine helps the body cells convert carbohydrates into energy.
- Riboflavin (B2): Is an antioxidant. Antioxidants stop molecules called free radicals from damaging your cells and causing disease. Riboflavin helps with eye health.
- Niacin (B3): Helps your digestive system, skin, and nerves function properly. Niacin may help you with your digestion, and some believe it helps relieve nausea.
- Pantothenic acid (B5): Helps your body make and break down the fats in the foods you eat. It also has a role in producing red blood cells, as well as sex- and stress-related hormones. Pantothenic acid may help relieve leg muscle cramps.
- Pyridoxine (B6): Plays an important part in brain development and function. It also helps make neurotransmitters (“messenger” cells) and the hormones serotonin and norepinephrine. Finally, pyridoxine helps make white blood cells and T cells, which are important for a healthy and strong immune system. Pyridoxine helps your baby’s brain and nervous system develop and might help you if you’re having nausea or trouble sleeping.
- Biotin (B7): Helps make fatty acids and glucose, both of which provide fuel for your body.
- Folate (B9): This B vitamin helps make your genetic material, the information in your body that is passed down from your parents. It also helps your body make red blood cells. Folic acid in the first few weeks of pregnancy helps reduce the chances of your baby having a neural tube defect like spina bifida. You should keep taking it throughout your pregnancy, though, because it also helps your body produce red blood cells.
- Cobalamin (B12): Also helps make genetic material and red blood cells and is important for keeping your nerve cells healthy. Cobalamin works with folic acid to help prevent neural tube defects.
The B vitamins help enzymes in your body do their jobs and are important for a wide range of cellular functions, like breaking down carbohydrates and transporting nutrients throughout the body. The B vitamins are essential for a fully functioning metabolism. The main function of the B vitamins is to help your body metabolize carbohydrates, proteins, and fats, and use the stored energy in food.
Read also: Optimize Well-being with Key Supplements
Potential Health Benefits of B Complex
In addition to their fundamental roles, B complex vitamins are associated with several potential health benefits:
- May Improve Brain Function: The B vitamins play a role in keeping your brain healthy. Adequate amounts of B vitamins in the body are essential for optimal body, brain, and nerve functioning. Research shows that vitamin B6 in particular may play a role in preventing the neurological disorder Parkinson’s disease.
- Possible Cancer Prevention: Data on the role of B vitamins in cancer prevention is mixed. Some studies found that certain B vitamins may help prevent some types of cancer, while others found evidence that high levels of B vitamins might cause some types of cancers. But there is strong evidence that taking vitamin B3 in supplement form - called nicotinamide - can greatly reduce the risk of non-melanoma skin cancer.
- May Improve Mood and Reduce Stress: If you have low levels of B vitamins, research shows you may be at a greater risk of depression and higher stress levels. Taking a B complex supplement can help you boost your blood levels to help you feel more calm and content. But it's unclear whether B vitamins have any added benefits for people with normal blood levels.
- May Improve Heart Health: Some studies show that certain people could improve their heart health if they take B vitamins, but it’s not recommended for everyone. If you would like to take vitamin B for your heart health, speak to your doctor first, to make sure there aren’t any reasons not to take it.
- May Improve Nerve Function: A lack of vitamin B, specifically vitamin B12, is linked to some problems with the nerves. Too little vitamin B12 can cause a painful condition called neuropathy. If you’ve been diagnosed with a vitamin B12 deficiency, your doctor will likely recommend a vitamin B12 supplement. But if you have neuropathy caused by another disease, like diabetes, experts aren’t sure if taking a vitamin B12 supplement will help ease the symptoms.
- May Strengthen the Immune System: More research is needed, but it seems that some forms of vitamin B may help help strengthen your immune system. For example, pyridoxine helps produce the white blood cells and T cells your body needs to boost your immune system.
- May Protect Gut Health: There are no studies that show healthy people who take vitamin B will strengthen their gut health. But some studies do show that taking vitamin B supplements helped improve appetite. Other studies showed that people with intestinal diseases, like inflammatory bowel disease (IBD), need extra vitamin B. If you have a bowel disease, your doctor may encourage you to eat more vitamin B-rich foods or may prescribe a supplement. These diseases can prevent your body from absorbing the vitamins from your food.
- May Maintain Healthy Red Blood Cell Levels: If you don’t have enough vitamin B12 or folate, your doctor may recommend you take supplements to help you maintain healthy red blood cell levels. Low levels could be caused by pernicious anemia, not consuming enough vitamins through your diet, or as a side effect of some medications.
Vitamin B Complex and Obesity: Exploring the Connection
Although studies have found a seemingly linked relationship between vitamin B and obesity, studies on the blood concentration of vitamin B and obesity are limited and inconsistent, and previous studies have mostly focused on vitamin B9 and vitamin B12.
Previous studies have found that obese people have lower levels of vitamin B, but most have focused on obesity as defined by body mass index (BMI), and its relationship with other types of obesity is unclear.
A recent study explored the relationship between vitamin B levels and obesity assessed by different definitions among Chinese middle-aged and older community-dwelling adults. The study included 887 participants aged 45 years and older (45-82 years). The concentrations of vitamin B (B1, B2, B6, and B9) were measured by robotic dry blood spot extraction systems in combination with liquid chromatography-tandem mass spectrometry. BMI, body fat percentage (BF%), visceral fat area (VFA), and waist circumference (WC) were used to diagnose obesity. VFA and BF% were assessed by bioelectrical impedance analysis. The logistic regression model was used to assess the associations between vitamin B levels and the odds of obesity.
The prevalence of obesity varied from 8.6% to 52.4% depending on different diagnostic criteria. After adjusting for covariates, a negative correlation was observed between vitamin B1 level and obesity according to the criteria of WC, VFA, and BF%, and the adjusted odds ratio (OR) was 0.47, 0.52, and 0.46, respectively. When using WC and BF% to define obesity, higher quartiles of vitamin B2 were negatively associated with the odds of obesity (OR: 0.62 and 0.62, respectively). Vitamin B6 was inversely associated with VFA-defined and BF%-defined obesity (OR: 0.64 and 0.64, respectively). When using VFA and BF% to define obesity, a negative correlation was observed in vitamin B9 (OR: 0.61 and 0.67, respectively).
Read also: Is Clinical Works Vitamin C Serum worth the hype? Find out here.
Key Findings:
- Vitamin B1 concentrations were negatively correlated with obesity (WC, VFA, and BF%).
- Vitamin B2 concentrations were negatively related with WC- and BF%-defined obesity.
- Both vitamin B6 and vitamin B9 were negatively associated with obesity when using VFA or BF% to define obesity.
These findings suggest that maintaining adequate levels of B vitamins, particularly B1, B2, B6, and B9, may play a role in preventing or managing obesity, especially in middle-aged and older adults.
The Role of Vitamin B in Metabolism and Weight Management
Vitamin B speeds up your metabolism by helping the body break down fat and protein in food and transform it into energy. Vitamin B regulates blood sugar levels, which is especially significant for diabetic patients.
The B vitamins are enzyme cofactors that play an important role in energy metabolism. A study in rats fed a high-fat diet found that B vitamin administration could reduce body weight gain by improving energy metabolism-related enzyme activities. The activities of transketolase (TK), glutathione reductase, and Na+/K+ adenosine triphosphatase were significantly increased in the B vitamin-treated groups. Furthermore, the glucose-6-phosphate dehydrogenase, pyruvic acid kinase, and succinate dehydrogenase activities also were increased after treatment with B vitamins.
Limitations and Inconsistencies in Research
Research on blood vitamin B and obesity is limited and inconsistent. Previous studies also found that vitamin B is associated with BMI, while the recent study did not.
A case-control study showed that serum folate levels were lower in obese subjects (BMI > 25 kg/m2) than in healthy controls, and serum folate was associated with BMI and waist to hip ratio. In a study of postmenopausal women, obese women (BMI > 30 kg/m2) had lower serum folate concentrations than normal-weight women, and serum folate was related to BMI and BF%. A cross-sectional study of Mexican-American children indicated that serum folate concentrations were negatively correlated with BMI and fat mass. Another study used five measurements to define obesity (BMI, WC, waist-to-height ratio, a body shape index, and body roundness index) and found that low levels of serum folic were associated with an increased odds of five types of obesity among middle-aged Koreans. Alternatively, a cross-sectional study with 57 healthy and 57 obese Emirati volunteers revealed that plasma pyridoxal levels were higher in obese participants than in healthy ones. The discrepancies in these findings highlight the need for further research to clarify the relationship between vitamin B and obesity.
Read also: Plant-Based K2 Guide
Signs of Vitamin B Deficiency
The signs of a vitamin B complex deficiency depend on which vitamins you are low on.
Symptoms of low thiamine (B1) include:
- A pins-and-needles sensation in your toes, burning in your feet (especially at night), muscle cramps, and heart abnormalities
- Confusion
- A hard time keeping your balance
- Vision changes
- Memory loss
If you're low in riboflavin (B2) you might have:
- Pale skin
- Cracks in the corner of your mouth and on the lips
- Sores in the mouth, on the tongue
- A magenta-colored tongue
- Patches that appear red, greasy, or scaly on your nose, above your lips, or on your ears, eyelids, and genitals
Low levels of niacin (B3) can cause:
- A sunburn-like rash that is worse on areas of the skin exposed to the sun
- An inflamed tongue
- Burning and sores in your mouth
- Burning in your throat
- Decreased saliva
- Nausea
- Vomiting
- Constipation
- Diarrhea, possibly with blood
- Fatigue
- Insomnia
- Confusion
- Disorientation
- Hallucinations
- Memory loss
- Depression
- Mania
- Paranoia
Pantothenic acid (B5) deficiency can cause:
- Numbness or burning in your hands and feet
- Headache
- Fatigue
- Crankiness
- Restlessness
- Insomnia
- Heartburn
- Diarrhea
- Nausea and vomiting
- Loss of appetite
Low pyridoxine (B6) symptoms are:
- Dermatitis
- A red, greasy, scaly rash
- Numb or prickling hands and feet
- A sore and red tongue
- Cracks in the corners of your mouth
- Confusion
- Crankiness
- Seizures
With low biotin (B7) levels, you might notice:
- Hair loss
- Dry, scaly skin
- Cracking in the corners of your mouth
- A swollen, painful tongue
- Dry eyes
- Loss of appetite
- Fatigue
- Insomnia
- Depression
Signs of a folate (B9) deficiency include:
- Fatigue
- Pale skin
- Shortness of breath
- Crankiness
- Dizziness
- A red, sore tongue
- Mouth sores
- Reduced sense of taste
- Memory loss
- A hard time concentrating
- Confusion
- Muscle weakness
- Depression
- Weight loss
- Diarrhea
Cobalamin (B12) deficiency causes:
- Rapid breathing
- Headaches
- Stomach upset
- Loss of appetite
- Heart palpitations
- Vision changes
- Fatigue
- Diarrhea
- A sore, red tongue
- Mouth sores
- Loss of memory
- Confusion
- Numbness or a pins-and-needles feeling
- Muscle weakness
- A hard time keeping your balance
- Incontinence (not able to hold your pee)
Obtaining B Vitamins Through Diet and Supplements
Ideally, you should get your daily vitamin B through your usual diet, but sometimes you may need some extra.
Food Sources of B Vitamins
If you want to increase vitamin B complex through your diet, there are many foods that are high in vitamin B, such as:
- Almonds
- Asparagus
- Atlantic salmon
- Avocado
- Banana
- Beef
- Black-eyed peas
- Tuna
- Broccoli
- Brown rice
- Brussels sprouts
- Cheese
- Chicken and turkey
- Chickpeas
- Clams
- Eggs
- Fortified breakfast cereal
- Milk
- Mustard greens
- Peanuts
- Pork
- Romaine lettuce
- Shitake mushrooms
- Sockeye salmon
- Spinach
- Sunflower seeds
- Sweet potato
- Yogurt
B Complex Supplements
Not everyone needs to take B complex supplements. You may need a supplement if you:
- Eat a vegetarian or vegan diet and don’t consume enough foods that contain the vitamins
- Take heartburn medications
- Have had weight loss surgery
- Have a disease that affects your stomach lining or gut, such as IBD or Crohn’s disease
- Have or are at risk of getting age-related macular degeneration (AMD)
- Are older and don’t get enough B vitamins through your diet
In many cases, you may not need a B complex supplement, but a single B vitamin supplement. For example, if you lack B12, but your levels of other vitamins are normal, then your doctor will likely suggest a B12 supplement.
B Complex Vitamin Shots
If you are low in vitamin B12, your doctor may recommend that you get B12 shots until the levels return to normal. Although there are vitamin B12 tablets, the shot seems to be more effective, boosting your levels more quickly and efficiently. Depending on what caused the low vitamin levels, you may have to continue having the shots, or you might be able to stop or switch to tablets when your levels get back to normal.
Potential Risks and Side Effects
Although B complex offers many health benefits and is essential to the body’s overall function, supplementing with B vitamins does carry some risk, especially at high dosages. B vitamins are water-soluble, so it’s difficult to overdose on them because your body will flush out the excess. While technically you could get too much vitamin B in your diet, it’s rare. But it is possible to have negative effects from too much of some of the vitamins if you take supplements. There don’t seem to be any health issues related to having too much thiamine, riboflavin, pantothenic acid, biotin, or cobalamin.
Although it is rare, too much niacin from supplements could cause red skin, tingling in the face, arms and chest, and itching. High niacin levels could also cause gout.
Too much pyridoxine could cause nerve pain in the hands and feet, loss of control of body movements (ataxia), and nausea.
Too much folic acid could cause your body to hide or mask a vitamin B12 (cobalamin) deficiency.
Lung Cancer
Although some B complex vitamins may help prevent cancer, there is evidence to show that too much of some types may increase the risk of lung cancer. One study found that people who got a lot of B12 from their diet were more likely to get lung cancer. Another study found that men who took vitamin B6 and B12 supplements were more likely to get lung cancer - especially if they smoked.
Peripheral Neuropathy
High amounts of vitamin B6, found in B complex supplements, can lead to a condition called peripheral neuropathy, which causes a loss of feeling in your hands and feet.
Liver Damage
B complex also contains niacin (vitamin B3). If you take high doses over a long period of time, niacin can damage the liver.
Important Considerations
- Consult a Healthcare Professional: If you’re considering taking a vitamin or supplement to assist with weight loss, talk with a doctor. They can discuss each product’s potential benefits and risks. Be sure to ask your doctor about possible interactions with any medications you might be taking. If you experience any side effects after taking a supplement, stop taking it and contact your doctor.
- Focus on a Balanced Diet: Most of your required vitamins, minerals, and other nutrients should come from food. Supplements can help fill in any gaps in your diet that come from a limited eating plan, but it’s best to get your nutrients from food if you can.
- Read Labels Carefully: Make sure to read the label thoroughly to check its active ingredients and to understand the correct dosage. It’s possible to overdose on certain vitamins if you’re not careful. Keep in mind that taking extra or mega doses of a vitamin or mineral supplement won’t help you. Also, note the expiration date prior to taking the supplement.
- Address Underlying Health Issues: If you’re trying to boost your energy because you’re constantly feeling under the weather or fatigued, see your doctor. This might be a symptom of a larger problem that vitamins can’t fix.
- Lifestyle Changes are Crucial: You’re unlikely to lose weight without also modifying how much you exercise and your calorie intake. Experts agree that the basis for long-term weight loss is following an overall balanced eating pattern, reducing caloric intake, and participating in physical activity.