The pursuit of effective and safe weight loss solutions is a common goal. Many individuals seek assistance in their weight loss journey, and prescription weight loss medications can provide that extra support needed to achieve meaningful results. Reveal Weight Loss offers prescription weight loss injections designed to boost metabolism by mimicking naturally occurring digestive hormones.
Understanding Weight Loss Medications
Weight loss medications work through different mechanisms. Some drugs promote a feeling of fullness or reduce hunger, while others limit the body's absorption of fat from food. When combined with a healthy lifestyle, prescription weight loss drugs can accelerate and enhance weight loss outcomes. Clinical data indicates that patients who adopt lifestyle changes and use prescription weight loss medications experience a 3% to 12% greater weight loss compared to those who only improve their diet and increase physical activity. Studies also suggest that patients can lose 10% to 15% of their total body weight with the support of prescription medication.
Administration and Side Effects
Prescription weight loss injections are typically administered under the skin in areas with excess fat, such as the abdomen, thigh, or upper arm. Most patients report minimal discomfort, describing the injection as a tiny prick. However, like all medications, prescription weight loss drugs carry potential risks and side effects. Weight loss injections like Zepbound and Wegovy, which are GLP-1 medications, may cause nausea, vomiting, diarrhea, constipation, and stomach upset. These side effects are generally mild and tend to subside as the body adjusts to the medication. It's important to combine GLP-1 weight loss medications with a healthy, low-calorie diet and regular exercise for optimal results.
The Evolving Landscape of Weight Loss Medications
The pharmacological treatment of obesity is continually evolving, requiring healthcare providers to stay informed about the latest developments. Before 2012, the FDA had approved only a limited number of weight loss medications. However, the 2020s witnessed a surge in the popularity and media attention surrounding glucagon-like peptide-1 receptor agonists (GLP-1 receptor agonists). Subsequently, dual receptor agonists like Mounjaro, indicated for type 2 diabetes, and Zepbound, indicated for obesity, emerged. In 2024, a significant number of adults were using GLP-1 medications for weight loss.
Choosing the Right Medication
With an expanding array of weight loss medications, patients often inquire about the most potent or effective option and which one is best suited for their individual needs. The answer is multifaceted, and newer medications are not always superior. Determining a patient's candidacy for weight loss medications involves assessing their BMI, current health issues, other medications, and family medical history. The average weight loss ranges from 5% to 21%, but individual results may vary. It's important to note that most people tend to regain weight if AOMs are discontinued. While some weight loss medications are FDA-approved only for adults, others, like semaglutide and liraglutide, are approved for children aged 12 and older with a BMI above the 95th percentile.
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First-Generation AOMs
While newer medications often dominate discussions, it's essential to consider first-generation AOMs, which may be appropriate for certain patients, especially when cost is a significant factor.
Specific Weight Loss Medications
Semaglutide (Wegovy, Ozempic)
Wegovy, a brand name for semaglutide, is a GLP-1 receptor agonist approved by the FDA in 2021. Administered as an injection, it is indicated for use in adults and children aged 12 years or more who have obesity (BMI ≥30 for adults, BMI ≥ 95th percentile for age and sex for children) or some adults with excess weight (BMI ≥27) and weight-related medical problems. The dosage is gradually increased over 16 to 20 weeks to reach the 2.4 mg dosage, which helps minimize side effects like gastrointestinal symptoms, headache, dizziness, and fatigue. Wegovy is intended for long-term use in conjunction with a healthy diet and exercise. Ozempic is another brand name for semaglutide.
Tirzepatide (Zepbound, Mounjaro)
Zepbound is approved for treating obesity in adults with a BMI of 30 or greater. It functions as both a GLP-1 and a GIP receptor agonist, reducing appetite and promoting weight loss when combined with diet and exercise. Mounjaro is another brand name for tirzepatide.
Liraglutide (Saxenda, Victoza)
Liraglutide is a daily injectable medication that acts on hormones, signaling fullness to the brain and reducing hunger. Doses range from 0.6 mg to 3 mg per day. Some patients may experience a 5-10% reduction in body weight, especially with higher doses. Liraglutide is also approved for Type 2 Diabetes under the brand name Victoza. Side effects can include nausea, diarrhea, constipation, vomiting, headache, decreased appetite, dyspepsia, fatigue, dizziness, abdominal pain, increased lipase, and renal insufficiency.
Phentermine
Phentermine is the oldest and most widely used weight loss medication. Initially intended for short-term use, medical guidelines now support its use in long-term therapy. Side effects may include headache, overstimulation, high blood pressure, insomnia, rapid or irregular heart rate, and tremor.
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Phentermine-Topiramate (Qsymia)
Topiramate can be combined with phentermine to suppress appetite and cravings. This combination is suitable for adults with migraines and obesity. Patients may experience an average weight loss of 5-10% of their body weight. Daily doses with four strengths range from 3.75 mg/23 mg to 15 mg/92 mg. Side effects can include abnormal sensations, dizziness, altered taste, insomnia, constipation, and dry mouth.
Naltrexone-Bupropion (Contrave)
Naltrexone-bupropion combines an opioid receptor antagonist with an antidepressant to target the pleasure-reward centers in the brain, reducing cravings and appetite. The starting dose is one 8/90 mg tablet daily, gradually increasing to four tablets a day. Common side effects include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.
Orlistat (Xenical, Alli)
Orlistat is a lipase inhibitor available in capsule form. It works by preventing the digestion of fat, which is then passed through the body. Patients may lose approximately 5% of their body weight. An over-the-counter formulation is available as 60 mg capsules to be taken with each fat-containing meal.
Setmelanotide
Setmelanotide is a melanocortin-4 receptor agonist indicated for chronic weight management in adult and pediatric patients aged six years and older who have obesity due to specific rare genetic disorders.
Plenity
Plenity is a medical device, not a medication, that was FDA-cleared in 2019 for individuals with a BMI of 25 to 40. It consists of a capsule that releases a biodegradable, super-absorbent hydrogel into the stomach. The gel enhances satiety, helping individuals eat less.
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Emerging Medications
With increasing demand for weight loss medications and rising obesity rates, more medications are expected to enter the market. Pharmaceutical platform Ozmosi predicts one to two GLP-1 launches annually starting in 2026, specifically for obesity. Lilly is developing at least two new options: orforglipron, an oral GLP-1 inhibitor that completed a Phase 3 clinical trial in early 2025, and retatrutide, which targets GLP-1, GIP, and glucagon and is currently in Phase 3 clinical trials. Amgen is developing MariTide, a once-monthly injection that increases GLP-1 receptor activity while reducing GIP receptor activity, which entered Phase 3 clinical trials in March 2025. Researchers are also studying other hormones, such as peptide tyrosine-tyrosine (PYY) and cholecystokinin (CCK), to identify new ways to target obesity with medication. The availability of more options will enable doctors to personalize treatments more effectively.
Comprehensive Treatment Plans
FDA-approved anti-obesity medications (AOMs) are safe and evidence-based therapies that target specific physiological mechanisms to improve the disease. They are most effective when used as part of a comprehensive treatment plan that includes medications, diet, exercise, and/or surgery. All weight loss medications work best when combined with a healthy eating plan and regular exercise. Some weight management medications are designed for short-term use, while others are for long-term use. Medications approved by the FDA for long-term use include orlistat (Xenical, Alli), phentermine-topiramate (Qsymia), naltrexone-bupropion (Contrave), liraglutide (Saxenda), semaglutide (Wegovy, Ozempic), and tirzepatide (Zepbound, Mounjaro). GLP-1s should not be stopped and restarted arbitrarily, as some require a lengthy ramp-up period of up to five months to reach the full dosage.
The Importance of Lifestyle Changes
Lifestyle changes are essential for sustainable weight loss. Reveal Weight Loss emphasizes the importance of nutrition and making better choices, transforming patients' attitudes from indifference to embracing a healthier life. The clinic provides patients with needed medication and a nutritionist who offers weekly guidance and coaching on proper nutritional tips.
Addressing Metabolic Adaptation
AOMs can help counteract the effects of metabolic adaptation and prevent weight regain. After weight reduction, the body undergoes metabolic changes, often leading to increased hunger hormones, decreased satiety hormones, and a reduced resting metabolic rate, all of which can contribute to weight regain.
Over-the-Counter Options
The only over-the-counter medicine for weight loss currently approved by the FDA is Alli (orlistat). Other over-the-counter products are considered supplements. Prescription medications allow healthcare professionals to assess all factors affecting a patient's lifestyle and BMI, monitor progress, and manage side effects.
The Role of Vitamins and Supplements
While no specific vitamin or supplement is considered a "treatment" for obesity or overweight, certain ones can support metabolic health. For instance, studies suggest that calcium and vitamin D may help regulate belly fat.
Medications That Can Cause Weight Gain
It's important to recognize that some medications can contribute to weight gain. These include certain antidepressants such as paroxetine (an SSRI) and amitriptyline, doxepin, and imipramine (tricyclic antidepressants). Bupropion (Wellbutrin), an aminoketone, is considered weight-negative and is sometimes prescribed to aid in weight loss and treat depression.
Considerations and Precautions
The guidelines for tirzepatide (Zepbound) and semaglutide (Wegovy) specify that patients should have a BMI of 30 or a BMI of 27 with weight-related health problems. These medications can also interfere with hormonal birth control. Older AOMs also have indications based on BMI and may be contraindicated for use with certain other medications.
Purchasing Medications Safely
It's crucial to purchase medications from reputable sources. The FDA advises against buying medications from any source other than a state-licensed pharmacy and has banned the sale of "counterfeit" semaglutide and tirzepatide. These counterfeit medications are compounded medications made by compounding pharmacies and have not been FDA-approved.
Potential Risks of Compounded Medications
Due to shortages, some patients have used compounded versions of medications, which are generally more affordable. However, the FDA has received numerous reports of adverse events associated with compounded semaglutide and tirzepatide.
Reveal Weight Loss: A Comprehensive Approach
Reveal Weight Loss is a dedicated endobariatric center in New Jersey that offers safe and effective non-surgical weight loss procedures. The center's team of board-certified experts has extensive experience in advanced endoscopic procedures. Reveal Weight Loss provides personalized attention, follow-ups, and a comprehensive approach to help patients achieve sustainable results.
Patient Experiences
Many patients have shared positive experiences with Reveal Weight Loss, praising the expertise and dedication of the staff, including Dr. Avik Sarkar and Dr. Haroon Shahid. Patients have reported significant weight loss, improved health, and a renewed sense of well-being. The clinic's commitment to providing personalized care and support throughout the weight loss journey has been consistently highlighted in patient testimonials.
One patient, Maria, expressed her satisfaction with the attention given by the staff and the success of her ESG procedure. Another patient lauded Dr. Shahid's excellent bedside manner and the exceptional aftercare provided by the team. Numerous patients have emphasized the professionalism, kindness, and responsiveness of the staff, particularly Carryll and Jennifer.
Debunking Weight Loss Myths
It's important to be wary of false claims and promises in weight loss ads. Claims of losing weight without dieting or exercising, not having to watch what you eat, permanent weight loss with a single product, rapid weight loss, or products that work for everyone are simply untrue. There is no magic way to lose weight without a sensible diet and regular exercise. Permanent weight loss requires permanent lifestyle changes.
Spotting False Promises
Dishonest advertisers often make unrealistic claims to entice consumers. Be cautious of products promising lightning-fast weight loss, as these can be harmful to your health. No product can guarantee weight loss for everyone, as individual habits and health concerns vary. Nothing applied to the skin can cause weight loss.
Recognizing Fake Stories Online
Scammers often create fake news reports and glowing online reviews to promote their products. They may use stock or altered photographs to depict dramatic weight loss results.