Mydayis is a prescription medication primarily used to treat attention deficit hyperactivity disorder (ADHD) in adults and children 13 years of age and older. It belongs to a class of medications called stimulants and contains a combination of four different amphetamine salts. This article provides a comprehensive overview of Mydayis, including its uses, dosage, side effects, warnings, and comparisons with other ADHD medications.
What is Mydayis?
Mydayis, also known as mixed amphetamine salts, is a stimulant medication prescribed for the treatment of ADHD. It comes in a triple-bead capsule formulated for extended-release, containing three types of beads with different coatings that release the medication at different times throughout the day. This extended-release formulation allows for once-daily dosing.
Mydayis contains four forms of the active drug amphetamine: dextroamphetamine sulfate, dextroamphetamine saccharate, amphetamine aspartate monohydrate, and amphetamine sulfate. The combination of these forms is called mixed amphetamine salts.
Uses of Mydayis
Mydayis is used to treat ADHD in adults and children ages 13 years and older. ADHD is a mental health condition that can cause problems such as having trouble paying attention or sitting still. Mydayis works by changing the amounts of certain natural substances in the brain, helping to increase the ability to pay attention, stay focused on an activity, and control behavior problems.
Dosage and Administration
Mydayis comes as an extended-release capsule that you take by mouth. The medication in each product is absorbed differently by the body, so one dextroamphetamine and amphetamine product cannot be substituted for another product. The Mydayis dosage your doctor prescribes will depend on several factors, including the severity of the condition being treated, your age, other medications you may be taking, and other medical conditions you may have.
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Typically, your doctor will start you on a low dosage and then adjust it over time to reach the amount that’s right for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.
For adults, the starting dose is typically a 12.5-mg capsule every day. If needed, your doctor may increase your dose by 12.5 mg each week. The maximum dose of Mydayis that you’d take is 50 mg once a day. Children will typically take a 12.5-mg capsule every day. If needed, their doctor may increase their dose by 12.5 mg after at least 1 week. The maximum dose of Mydayis that a child would take would be 25 mg once a day.
Mydayis is usually taken upon awakening and must be taken consistently either with or without food. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
You can take Mydayis by swallowing the capsule. Or you can open the capsule and pour the drug on a spoonful of applesauce, which you then swallow without chewing right away. Do not store the applesauce and medication mixture for future use, and do not divide the contents of one capsule into more than one dose. Swallow this mixture right away without chewing.
If you miss your dose of the extended-release capsule in the morning, skip the missed dose and take your next dose at the regular time the next day. Do not take a dose later in the day. Do not take a double dose to make up for a missed one. Avoid taking Mydayis too close to bedtime, as you may have trouble falling asleep.
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Side Effects of Mydayis
Dextroamphetamine and amphetamine may cause side effects. Some side effects are more common, while others are more serious but less frequent.
Common Side Effects
Some of the more commonly reported side effects of Mydayis include:
- Nervousness
- Headache
- Changes in sex drive or ability
- Painful menstrual cramps
- Dry mouth
- Constipation
- Diarrhea
- Nausea
- Weight loss
- Anxiety
- Insomnia
- Decreased appetite
Serious Side Effects
Some side effects can be serious. If you experience any of the following symptoms, call your doctor right away and get emergency help:
- Slow or difficult speech
- Dizziness
- Weakness or numbness of an arm or leg
- Seizures
- Motor or verbal tics
- Teeth grinding
- Depression
- Believing things that are not true
- Feeling unusually suspicious of others
- Hallucinating (seeing things or hearing voices that do not exist)
- Agitation, hallucinations, fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea
- Mania (frenzied or abnormally excited mood)
- Changes in vision or blurred vision
- Paleness or blue color of fingers or toes
- Pain, numbness, burning, or tingling in the hands or feet
- Unexplained wounds appearing on fingers or toes
- Blistering or peeling skin
- Rash
- Hives
- Itching
- Swelling of the eyes, face, tongue, or throat
- Difficulty breathing or swallowing
- Hoarseness
- Fast or irregular heartbeat
- Fainting
- Coma (loss of consciousness for a period of time)
Dextroamphetamine and amphetamine may cause sudden death in children and teenagers, especially children or teenagers with heart defects or serious heart problems. This medication also may cause sudden death, heart attack, or stroke in adults, especially adults with heart defects or serious heart problems.
Side Effects in Children
In studies of Mydayis, side effects were similar for children and adults. However, children were more likely to experience nausea, upper abdominal pain, and dizziness compared with adults. Also, slowed growth is commonly reported in children taking amphetamines (such as Mydayis) to treat ADHD. During your child’s Mydayis treatment, their doctor will keep track of their height and weight. If your child’s growth shows signs of being affected, their doctor may recommend temporarily stopping Mydayis treatment.
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Weight Loss
On June 30, 2025, the FDA issued a drug safety communication about a risk of weight loss in patients younger than 6 years of age taking extended-release stimulants for ADHD and will be revising the labeling for all these products to reflect this new safety information. Although extended-release stimulants are not approved for children younger than 6 years, health care professionals can prescribe them “off label” to treat ADHD.
If parents or guardians notice weight loss in their child taking an extended-release stimulant for ADHD, they should contact their pediatrician or other health care professional to discuss whether the benefits of continued treatment outweigh the risks. Weight loss in young children may contribute to nutritional deficiencies, impaired growth, lower energy levels, and other adverse effects.
Allergic Reaction
Like most drugs, Mydayis can cause an allergic reaction in some people. Symptoms can be mild to serious and can include skin rash, itchiness, flushing, swelling under your skin, and swelling of your mouth, tongue, or throat, which can make it hard to breathe. If you have symptoms of a severe allergic reaction, such as swelling or difficulty breathing, call 911 or your local emergency number right away.
Warnings and Precautions
Before taking Mydayis, tell your doctor if you have glaucoma, hyperthyroidism, or feelings of anxiety, tension, or agitation. Also, tell your doctor if you have an abnormal electroencephalogram (EEG; a test that measures electrical activity in the brain), or liver or kidney disease.
Mydayis has a boxed warning for the risks of misuse and addiction. This is the most serious warning from the Food and Drug Administration (FDA). Mydayis is a Schedule II controlled substance, which means it carries a high risk of misuse. Before prescribing Mydayis, your doctor will assess your risk of misuse and addiction. While you’re taking this medication, your doctor will also monitor you for signs of misuse or addiction.
It is important to store dextroamphetamine and amphetamine in a safe place so that no one else can take it accidentally or on purpose. Keep track of how many tablets or capsules are left so you will know if any are missing.
Drug Interactions
Tell your doctor or pharmacist if you are taking the following medications or have stopped taking them within the past two weeks: monoamine oxidase (MAO) inhibitors including isocarboxazid, linezolid, methylene blue, phenelzine, selegiline, or tranylcypromine.
Some medications should not be taken with dextroamphetamine and amphetamine. Other medications may cause dosing changes or extra monitoring when taken with dextroamphetamine and amphetamine. Make sure you have discussed any medications you are currently taking or plan to take before starting dextroamphetamine and amphetamine with your doctor and pharmacist. Before starting, stopping, or changing any medications while taking dextroamphetamine and amphetamine, please get the advice of your doctor or pharmacist.
The following nonprescription or herbal products may interact with dextroamphetamine and amphetamine: St. Be sure to let your doctor and pharmacist know that you are taking these medications before you start taking dextroamphetamine and amphetamine. Do not start any of these medications while taking dextroamphetamine and amphetamine without discussing with your healthcare provider.
Pregnancy and Breastfeeding
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking dextroamphetamine and amphetamine, call your doctor. Do not breastfeed while taking dextroamphetamine and amphetamine.
Other Warnings
Talk to your doctor about the risks and benefits of taking dextroamphetamine and amphetamine if you are 65 years of age or older. Do not drive a car or operate machinery until you know how this medication affects you.
You should know that dextroamphetamine and amphetamine should be used as part of a total treatment program for ADHD, which may include counseling and special education.
Mydayis vs. Other ADHD Medications
Mydayis is often compared to other medications used to treat ADHD, such as Adderall XR and Vyvanse. All three medications are stimulants and contain amphetamine-based drugs, but they differ in their formulations, dosages, and approved uses.
Mydayis vs. Adderall XR
Both Mydayis and Adderall XR contain four forms of the active drug amphetamine and are FDA-approved to treat ADHD. However, they are manufactured in different ways to release the active drug over time and come in different doses.
Adderall XR is available in two forms: an extended-release capsule and an immediate-release tablet. Mydayis comes as an extended-release capsule. A key difference between Mydayis and Adderall XR is the long-lasting formulation that Mydayis affords. Because the drug can last up to 16 hours, only one dose per day is required.
Mydayis vs. Vyvanse
Both Mydayis and Vyvanse are prescription medications that belong to a drug class called stimulants and are FDA-approved to treat ADHD in adults. Mydayis is also approved for children ages 13 years and older, while Vyvanse is approved for children ages 6 years and older. In addition, Vyvanse is also approved to treat binge eating disorder.
Mydayis contains four forms of the active drug amphetamine, while Vyvanse contains the active drug lisdexamfetamine dimesylate. Lisdexamfetamine is a prodrug, meaning it is inactive until it is converted in the body to its active ingredient, dextroamphetamine.
Misuse and Addiction
Mydayis is a Schedule II controlled substance, meaning it has a high potential for abuse and addiction. Taking more of the drug than is prescribed or taking the drug in a manner that is not in keeping with recommendations can result in a Mydayis “high” and could lead to the development of tolerance, dependency, and addiction.
Misuse of Mydayis increases the risk of developing substance use disorder and overdose. Symptoms of Mydayis overdose include feeling restless, jittery, or shaky, panic attack, flu-like symptoms, fast breathing, agitation, confusion, and hallucinations, body temperature higher than 104°F (40°C), seizures, and fast and irregular heart rate, which may lead to heart attack or stroke. An overdose of Mydayis may even lead to coma or be fatal.
If you suspect someone has taken too much of the drug, it’s important to seek emergency medical care.