InSea2® is a proprietary form of brown seaweed extract. It is marketed as a natural ingredient with the potential to support healthy glucose metabolism, weight management, and cognitive function. It is used every day by some people who would buy it again. This article delves into the science behind InSea2, exploring its potential benefits, mechanisms of action, and important considerations.
Understanding Blood Sugar and Its Impact
Even health-conscious, active people can experience higher-than-optimal blood sugar levels as they age. Each year, about 1.6 million people aged 20 or older are diagnosed with diabetes. According to the American Diabetes Association, of the 23.6 million children and adults that currently have the disease-7.8 percent of the US population-5.7 million do not know they have it. It is estimated that 57 million adults aged 20 and older have pre-diabetes, type 1 diabetes accounts for five to 10 percent of all diagnosed cases and type 2 diabetes accounts for 90-95 percent of all diagnosed cases, and is increasingly being diagnosed in children and adolescents. In addition, the American Institutes of Health estimates that over 65 percent of Americans are either overweight or obese and the number is climbing.
Maintaining already-healthy glucose levels is a concern for many, driving interest in natural products that help control blood sugar. Consumer awareness of blood sugar health has increased, partly due to low-carb and low glycemic index trends. There has been an increased consumer awareness of blood sugar health, in part due to the low-carb, low glycemic index trends that have occurred over the past decade. We’ve also learned more in the past decade about how blood sugar health affects weight management and energy levels.
InSea2: A Dual-Action Approach to Carbohydrate Management
InSea2® is an optimized blend of polyphenols derived from two species of brown seaweed. According to innoVactiv, InSea2 is the only product on the market today that exhibits a dual mechanism of action against digestive enzymes involved in carbohydrate digestion and assimilation. As one of the key ingredients in the Natural Glucose Absorption Control formulation, InSea2 selectively targets digestive enzymes involved in carbohydrate digestion and diminishes the metabolic impact following a high-GI meal.
How InSea2 Works
InSea2® inhibits glucosidase and amylase-enzymes that break down carbohydrates into glucose, facilitating its transport into the bloodstream. InSea2 has demonstrated potent inhibiting effects against both á-glucosidase and á-amylase enzymes. By consuming InSea2 and targeting these enzymes, the rate of carbohydrate digestion and absorption can be significantly slowed, potentially reducing the caloric impact of foods rich in starch and sugar. This dual-action mechanism is key to its potential benefits.
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Clinical Evidence for InSea2's Efficacy
In a randomized, double-blinded, placebo-controlled, crossover human clinical trial led by the Institute of Nutraceuticals and Functional Foods of Laval University (Quebec, Canada), InSea2 produced a statistically significant 48 percent decrease in the normal glycemic response that follows ingestion of a standardized meal (white bread, P = 0.046) in 23 healthy volunteers. InSea2 also induced a 22 percent reduction in initial insulin production (P = 0.045) and an overall 12 percent reduction in the area under the curve of the insulin response (P =0. 031). Even more interesting was the fact that InSea2 improved insulin sensitivity by eight percent (Cederholm index, P = 0.047) after a single use of the product.
Benefits of InSea2
Blood Sugar Management
InSea2 is used in products for helping to maintain already-healthy glucose levels. InSea2 helps regulate blood sugar levels and also reduces post-meal glucose spikes, making it an excellent choice for individuals aiming to manage their glycemic response effectively. InSea2 thus reduces the fluctuations in blood sugar induced by dietary carbohydrates, while reducing insulin levels and improving surrogate markers of insulin sensitivity.
Weight Management and Satiety
Slendesta’s satiety benefits, along with the satiety effects of another ingredient, InSea2, were recently examined as part of a randomized, double-blind, placebo-controlled study on Gly-Sea-Max, a branded dietary supplement by Douglas Laboratories. The company promotes Gly-Sea-Max for supporting normal glycemic response, satiety, and fullness. (Rimouski, QC, Canada), is a polyphenolic algal extract said to inhibit digestive enzymes alpha-amylase and alpha-glucosidase. Gly-Sea-Max study was completed by 38 male and female volunteers. According to researchers, the active-ingredient group showed greater increases in satiety after consuming a meal, compared to placebo.
Cognitive Function
The relationship between plasma glucose and cognitive function follows an inverted-U dose response curve and as such, it is beneficial to control the amount of glucose available from food in order to avoid large deviations from the optimal required for cognitive functioning. Although the brain relies on glucose for energy production, its optimal functioning is affected when blood glucose levels fluctuate up and down after a high-carb meal. Several studies have shown that attention, cognition, and even driving can be impaired after a meal due to occurrence of postprandial hypoglycemia or to amino acid imbalances in the brain’s chemistry that induce sleepiness.
New study results have demonstrated for the first time the superior potency of InSea2 against free radicals, according to innoVactiv, a Canadian company dedicated to the development of science-based specialty ingredients. The present randomized, double-blind, placebo-controlled study involved 60 healthy male and female subjects. On study day, each volunteer underwent baseline cognitive tests to measure Attention, Performance and Error rate using the Computerised Mental Performance Assessment System (COMPASS). Subjects then took 500 mg of InSea2 before eating a high-carb meal. Cognitive tests were repeated every 40 minutes over a 3 hour and 10 minute period. Results showed statistically-significant improvements in cognitive function, such as increased accuracy on Digit Vigilance and Choice Reaction tests. The InSea2-treated subjects were also significantly less likely to make errors in repetitive, computer tasks.
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Antioxidant Properties
Free radicals are a driving force behind aging processes and their production is stimulated when blood glucose and insulin levels are high, such as after a meal. InSea2 can reduce oxidative stress not only through its clinically-demonstrated optimizing action on blood sugar, but also by acting itself as a source of high potency antioxidants with demonstrated bioavailability.
Formulations and Combinations
Berberine with InSea2 is a groundbreaking supplement expertly formulated to optimize metabolic health and promote effective blood sugar management.
CinSulin® with InSea2® and Crominex® 3+ combines cinnamon and seaweed extracts with a patented chromium complex for potent healthy glucose metabolism support. CinSulin® Cinnamon water extract (bark) [std.
Safety and Considerations
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Potential Side Effects
While InSea2 is generally considered safe, more research is needed to fully understand its potential side effects in all populations.
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Interactions
It's always best to consult with a healthcare professional before starting any new supplement, especially if you have existing health conditions or are taking medications.