Estarylla is a combination oral contraceptive pill (cOCP), also known as birth control medication or birth control pills, containing ethinyl estradiol and norgestimate. It is designed to prevent pregnancy by preventing ovulation, thickening the cervical mucus to block sperm, and altering the uterine lining to prevent implantation. This medication is also prescribed to treat acne in women. The drug was first invented in 1938 by Hans Herloff Inhoffen and Walter Hohlweg, who worked for Schering. They added an ethinyl group to the chemical estradiol, which made it more easily absorbed in the body when taken orally. This drug is now used in many birth control pills and was approved by the FDA in 1943.
What is Estarylla?
Estarylla combines ethinyl estradiol, a synthetic estrogen, with norgestimate, a progestin. Ethinyl estradiol has strong estrogenic activity, while norgestimate, a third-generation progestin, has lower androgenic effects and relatively no estrogenic effects. Estarylla acts as a combined hormonal contraceptive suitable for women until menopause, with the choice based on individual needs, health conditions, risk factors, and preferences.
How Estarylla Works in the Body
Ethinylestradiol is a synthetic form of the female hormone estrogen. Taking it reduces bone density and suppresses ovulation by stopping hormones from being released. It also thickens the mucus in the cervix and prevents changes in the endometrium that are needed for fertilization. It decreases luteinizing hormone, which decreases vascularity in the uterus, and it increases sex hormone binding globulin.
Estarylla Uses
Approved by the FDA, Ethinylestradiol, also known as LOESTRIN Fe 1.5/30, is approved by the FDA for Birth Control. It is used to treat Contraception in combination with Levonorgestrel. Additionally, it is also approved as an adjunct treatment for acne in premenopausal women. There are 38 active studies are currently evaluating the potential of Tri-Estarylla in providing Folate supplementation therapy, relieving Premenstrual Dysphoric Disorder and alleviating Menopausal symptoms.
Dosage and Administration
Estarylla is taken orally in tablet form. Taking it with food, after dinner, or before bed may help reduce nausea. It should be taken at the same time each day to maximize contraceptive effectiveness and maintain a routine. Estarylla is packaged in a 28-tablet blister pack, with 21 active hormone tablets and 7 iron or inert tablets to maintain a continuous regimen.
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What to do if you miss a dose
If a dose is missed, take it as soon as remembered, and take the next tablet at the usual time, even if it means taking two tablets on the same day. If two consecutive doses are missed, take both pills, one on the day the missed dose is remembered and one on the following day, then resume the usual schedule. In both cases, use a non-hormonal contraceptive method for at least 7 days after restarting the medication. If more than three consecutive doses are missed, skip the missed pills and restart the medication cycle from the beginning, using a non-hormonal contraceptive method for at least 7 days.
Precautions and Warnings
It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and does not cause unwanted effects. These visits will usually be every 6 to 12 months, but some doctors require them more often. Your doctor may also want to check your blood pressure while taking this medicine. Although you are using this medicine to prevent pregnancy, you should know that using this medicine while you are pregnant could harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away. Make sure your doctor knows if you had given birth within 4 weeks before you start using this medicine. Do not use this medicine together with medicine to treat hepatitis C virus infection, including ombitasvir/paritaprevir/ritonavir, with or without dasabuvir (Technivie®, Viekira Pak®). This medicine will not protect you from getting HIV/AIDS, herpes, or other sexually transmitted diseases. Tell your doctor if you or your partner begin to have sexual intercourse with other people, or you or your partner tests positive for a sexually transmitted disease. If this is a concern for you, talk with your doctor.
Potential Side Effects
Estarylla, containing hormones, can affect various organs, leading to undesirable signs. Women may experience:
- Changes in breast tissue or nipple discharge
- Abnormal vaginal bleeding between menstrual cycles
- Changes in menstrual patterns
- Breast tenderness
- Coughing up blood
- Dizziness or fainting
- Headaches or migraines
- Pain in the legs, arms, or groin
- Swelling in the legs
- Stomach pain
- Sudden shortness of breath
- Sudden loss of coordination
- Speech problems
- Symptoms of vaginal infections
- Upper abdominal pain
- Vomiting
- Weakness or numbness
- Yellowing of the eyes or skin
- Mood changes, anxiety, depression
- Skin rashes, acne, or increased skin pigmentation
- Weight gain
If these symptoms appear suddenly or worsen rapidly, consult a doctor immediately. Discontinuation of the medication and alternative contraception may be necessary.
Important Considerations
During Estarylla use, regular health check-ups are essential to detect abnormalities caused by hormonal effects, including breast and pelvic exams, mammograms, and Pap smears. Estarylla can cause fluid retention, leading to swelling in the fingers, hands, or ankles, and may increase blood pressure. In such cases, consult a doctor for an alternative contraceptive method.
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An additional contraceptive method should be used during the first cycle of Estarylla and in case of missed doses. If pregnancy is suspected, stop using the medication immediately and contact a doctor.
Contraindications
Women who smoke and are over 35 years old should not use Estarylla due to the increased risk of blood clots or stroke.
Sun Sensitivity
Hormonal contraceptives can increase skin sensitivity to sunlight. Avoid sun exposure, wear protective clothing, use sunscreen, and wear a wide-brimmed hat when outdoors.
Contact Lenses
If you wear contact lenses and notice visual changes, consult an eye care specialist.
Dental Health
Some women may experience swollen or bleeding gums. Visit a dentist to rule out oral diseases and use a soft toothbrush and floss regularly.
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Surgery
Estarylla should be discontinued before surgery.
STIs
Estarylla does not protect against HIV/AIDS or other sexually transmitted diseases.
Common Tri-Estarylla Drug Interactions
There are 20 known major drug interactions with Tri-Estarylla.
Tri-Estarylla Contraindications
Tri-Estarylla has twenty-six contraindications and should be avoided in cases of the conditions listed in the table below.
Tri-Estarylla Toxicity & Overdose Risk
Women who overdose on birth control pills may experience bleeding, nausea, vomiting, breast tenderness, abdominal pain, drowsiness, and fatigue. Treatment should include monitoring of potassium, sodium, and signs of metabolic acidosis, as well as providing symptomatic and supportive care.
Estarylla and Weight Gain
There is no direct link between Tri Estarylla and weight gain. Some women experience changes in their appetite that may lead to weight gain while taking Tri Estarylla.
Patient Reviews
Tri-Estarylla generally receives positive feedback regarding its efficacy for contraception, with physicians assessing it favorably in this regard. However, individual experiences vary. Some users have reported positive results, such as:
- Acne Improvement: Many users have reported significant improvements in acne, with clearer skin and fading dark scars.
- Painful Periods Relief: Some users have experienced lighter and less painful periods.
- Effective Birth Control: Many users are pleased with its effectiveness in preventing pregnancy.
However, some users have reported negative experiences, such as:
- Mood Swings and Depression: Some users have reported mood swings, depression, and irritability.
- Menstrual Irregularities: Some users have experienced prolonged or heavy periods, or spotting.
- Acne Worsening: In some cases, acne has worsened with Estarylla use.
- Other Side Effects: Other reported side effects include nausea, anxiety, and a bitter taste in the mouth.
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