Kratom, derived from the leaves of the Mitragyna speciosa tree native to Southeast Asia, has garnered attention for its potential health benefits, including weight loss. This article explores the reported benefits of kratom for weight loss, examines appropriate dosages, and discusses safety considerations.
Introduction to Kratom
Mitragyna speciosa, commonly known as kratom, is an evergreen tree that grows in Southeast Asia. For centuries, people in this region have traditionally used kratom for its medicinal properties. The leaves are typically dried and consumed in various forms, including teas, capsules, and powders. Kratom is reported to act as a stimulant at low doses, increasing alertness and energy, while higher doses are believed to have sedative and pain-relieving effects.
Potential Weight Loss Benefits of Kratom
Several studies suggest that kratom may have potential benefits for weight loss.
Appetite Suppression
Early studies suggest that kratom may act as a hunger suppressant. In one animal study, kratom supplementation was found to inhibit the hypothalamus, the part of the brain responsible for appetite and cravings, in rats. However, more research is needed to determine if kratom has similar effects in humans.
Effects on Metabolic Syndrome
A cross-sectional study conducted in Thailand examined the effects of kratom use on parameters related to metabolic syndrome (MetS). The study, involving 581 participants (kratom users and non-users), found that kratom use was associated with lower odds of MetS. Specifically, kratom users had significantly lower waist circumference and body mass index (BMI).
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Impact on Lipid Profiles
Research indicates that regular use of Thai kratom may lower blood triglyceride levels and BMI compared to non-users. Studies have also explored the effects of Green Thai Kratom (GTK) and Red Thai Kratom (RTK) on pancreatic digestive enzymes. The ethanol extracts of GTK and RTK inhibited lipase activity more strongly than alpha-glucosidase activity, suggesting the presence of lipase inhibitors. Mitragynine, the major compound in GTK, showed potent lipase inhibition and moderate alpha-glucosidase inhibition.
Inhibition of Fat Accumulation
Both GTK and RTK extracts have been shown to reduce fat accumulation in 3T3-L1 adipocyte cells, with quercetin specifically inhibiting Acetyl-CoA carboxylase 1 (ACC1), a key enzyme in fatty acid biosynthesis. This suggests that kratom extracts, particularly mitragynine and quercetin, may exhibit potential anti-obesity effects.
Kratom Dosage for Weight Loss
Kratom does not have FDA approval to treat any condition, so there is no specific recommended dose. Early studies suggest that doses below 5 grams of raw plant material may act as a stimulant, similar to caffeine. Higher doses between about 5 and 15 grams may have the opposite effect and may help relieve pain.
Forms of Kratom Consumption
Kratom can be consumed in various forms, including:
- Kratom Drink: Mixing the powder form of the plant with water or adding liquid from the kratom plant into a drink.
- Kratom Toss-and-Wash: Taking a scoop of kratom powder by mouth and drinking water immediately after.
- Kratom Tea: Brewing the leaves of the kratom plant to make tea.
- Kratom Capsules: Swallowing capsules containing crushed kratom leaves.
- Other Kratom Products: Chewing or smoking the leaves, or taking kratom extract.
Safety Concerns and Side Effects
It is crucial to be aware of the potential risks and side effects associated with kratom use. The FDA has warned people against using kratom due to possible harm it can cause.
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Reported Side Effects
Common side effects of kratom include nausea and constipation. Some users may experience sweating, itching, dizziness, drowsiness, and dry mouth. Rare but serious side effects include hallucinations, seizures, liver damage, confusion, tremors, high blood pressure, and slow breathing.
Liver Problems
Kratom can cause liver problems, such as acute liver injury and, in rare cases, acute liver failure.
Interactions with Other Medicines
Kratom has been reported to react with other medicines, potentially leading to severe effects, such as liver damage and death. If kratom is used with other stimulants, such as caffeine, its effects will be worse. Likewise, if it is taken with any other substances that cause sedation, it can worsen that effect and even lead to respiratory depression and breathing trouble.
Addiction and Withdrawal
Kratom may be addictive if it causes you to continue using it despite any negative effects. After regular and prolonged kratom use, reports have included the following withdrawal symptoms: hostility, aggression, inability to work, muscle and bone pain, jerky movements of the limbs, nausea and vomiting, chills, diarrhea, hypothermia, sweating, drooling, restlessness and irritability, tremors, nervousness and anxiety, and depression.
Contamination
Kratom products have been found to have heavy metals, such as lead, and harmful germs, such as salmonella, in them. Salmonella poisoning can be fatal.
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Legal Status and Regulation
Kratom is not regulated in the United States. However, federal agencies are taking action to fight false claims about kratom. The use and sale of kratom are banned or controlled in many countries. For example, kratom is illegal in countries such as Singapore, Denmark, France, and Croatia.